EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057

EGFR(T790M/V948R) in complex with the allosteric inhibitor FRF-06-057 Descriptor: (2R)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-2-phenyl-N-(1,3-thiazol-2-yl)acetamide, Epidermal growth factor receptor, MAGNESIUM ION, ... Authors: Chitnis, S.P, Deng, M.Q, Pham, C.P, Heppner, D.E. Deposit date: 2023-08-02 Release date: 2024-08-28 Last modified: 2025-03-12 Method: X-RAY DIFFRACTION (2.99 Å) Cite: Tilting the Scales toward EGFR Mutant Selectivity: Expanding the Scope of Bivalent "Type V" Kinase Inhibitors. J.Med.Chem., 67, 2024