Results of the validation analysis in the 74,033 remaining samples in the UK Biobank.

The two sets m4 and m3 were identified in the corresponding main analysis (Table 2) and correspond to the results of the RITSS1 analysis. The interactions between the scores (corresponding to m4 and m3 respectively) and the environmental factor Eit were tested using a linear regression, adjusting for all Xi, Ei and Zi. The robust p-values are based on standard errors obtained by a robust sandwich variance estimator. P-Y-S: pack-years of smoking.