Single-cell and bulk RNA sequencing of mouse atherosclerosis disease stage course [adipose_liver_bulkRNA]

In addition to the pathological processes in the vascular wall, atherosclerotic coronary artery disease (CAD) development is affected other tissues, including metabolic tissues such as liver and white adipose tissue (WAT). However, the transcriptional events occurring in metabolic tissues in response to pro-atherosclerotic conditions (hypercholesterolemia and obesogenic diet), remain incompletely understood. Here, we profile liver and WAT gene expression in mouse at increasing exposure levels of atherogenic factors.除血管壁的病理进程外，动脉粥样硬化性冠状动脉疾病（atherosclerotic coronary artery disease, CAD）的发生发展还受其他组织影响，其中包括肝脏、白色脂肪组织（white adipose tissue, WAT）等代谢组织。然而，代谢组织在响应致动脉粥样硬化状态（高胆固醇血症与致肥胖饮食）时所发生的转录事件，其完整机制仍未被完全阐明。本研究对暴露于递增剂量致动脉粥样硬化因子的小鼠，开展肝脏与白色脂肪组织的基因表达谱分析。