Comparison of gene expression profiles between IGFBP-2-knockdown and control glioblastoma cell line U251. Homo sapiens

To examine the role of IGFBP-2 in gliuoblastoma (GBM) cell function, we used short hairpin RNA (shRNA) directed against IGFBP-2 mRNA. We constructed retroviral vectors which showed stable and significant silencing effects on IGFBP-2 genes of two different human GBM cell lines, U251 and YKG-1. Expression profiles of IGFBP-2-knockdown U251 with those from control cells are shown.