Effects of drug treatment on cytokine concentrations in supernatants of restimulated PBLN cells from the acute exacerbation model.

Values are pg/mL, shown as mean ± SEM (n = 3 samples per group, pooled pairs from 6 animals). Significant differences compared to naïve animals are shown as *(p<0.05), **(p<0.01) and ***(p<0.001); compared to the vehicle-treated group as #(p<0.05) and ##(p<0.01). For technical reasons, sufficient numbers of cells could not be collected from animals treated with 20 mg/kg of ISU201.