Genotyping analysis employing Illumina Infinium ImmunoArray-24 v2.0 BeadChip. Genotyping analysis employing Illumina Infinium ImmunoArray-24 v2.0 BeadChip

Mucosal host DNA methylation was associated with the presence of inflammation suggesting epigenetic changes in response to the microbiota. Hierarchical clustering of the microbiota indicated ten subgroups, whereas some were driven by certain Enterbacteriacae and Bacteroides keystone species, and which were associated with host genotype and DNA methylation profiles, but with little influence from the habitual diet. Overall design: Genetic samples from 170 patients were genotyped and analysed for correlation with condition, status and assocation to micobiota clustered subgroups.