Klebsiella quasipneumoniae Genome sequencing. Klebsiella quasipneumoniae

The dissemination of carbapenem-resistant gram-negative bacteria (GNB) represents a significant global public health concern, largely attributable to the misuse of antibiotics in clinical treatment. The primary mechanism of carbapenem resistance is the acquisition of carbapenemases. Furthermore, many reports indicated that the membrane proteins of Enterobacteriaceae also contribute to antimicrobial resistance. Therefore, any variation of membrane proteins may exert a more pronounced influence on antibiotic resistance levels. Our study provides a new approach to antibiotic resistance in Klebsiella pneumoniae, which may be an alternative to plasmids transformation and a concern for antibiotic therapy in the future.