Impact of immune parameters on clinical outcome after islet cell transplantation.

Shown are univariate and stepwise multivariate analyses for time to insulin independence (A), Insulin independence at one year (B), and total C-peptide level over one year (C). Parameters significantly associated with outcome are depicted in bold. *logrank test; ** Cox proportional hazard regression; † Mann-Whitney U test/Fischer's exact test/χ2 test; †† logistic regression; ‡ Pearson's correlation/unpaired t-test/one-way ANOVA; ‡‡ linear regression; + average Tacrolimus trough level in months 0–3 analyzed for endpoint A, in months 0–12 for endpoint B and C. When more than two groups are analyzed, the univariate columns refer to overall p-values. I.I.:insulin independence; R.R.: relative risk; C.I.: confidence interval; S.E.: standard error.