MISC Data Entry.xlsx

As a post-COVID complication in children, multisystem inflammatory syndrome in children (MIS-C) is important because of its varied and life-threatening manifestations. With this background, this study attempts to focus on MIS-C cases in an underprivileged rural setting in north-eastern India, with most patients being treated with methylprednisolone rather than intravenous immunoglobulin due to financial constraints<strong>. </strong> <em>Methods </em> In this prospective longitudinal cohort study at MGM Medical College, 27 MIS-C cases diagnosed following WHO criteria were included. Laboratory and radiological investigations, including echocardiography, were performed as required for diagnosis and to assess prognosis. Most patients were treated with methylprednisolone. A follow-up assessment was done six weeks after discharge for any residual impairment. <em>Results </em> The most frequently affected age group was 5–10 years (59.28%), while respiratory (48.14%) and cardiac (40.74%) were the most commonly involved systems. Logistic regression studies established a significant association between serum ferritin level and prolonged hospital stay (coefficient 0.0674, p=0.0041), possibly due to greater complications in cases with high ferritin levels. Organ impairment was found to increase the need for inotrope use (coefficient 3.8797, p=0.00584). Most cases were treated with methylprednisolone alone (85.18%) with a favourable response and no death occurred. <em><strong>Conclusion</strong></em> The favourable response in cases treated with methylprednisolone only affirms the effectiveness of the drug as a cheaper alternative in a resource-poor setting. The study highlights that higher ferritin levels in complicated cases leads to prolonged hospitalisation and the increased need for inotropes in cases with organ impairment.儿童新冠后并发症——儿童多系统炎症综合征（multisystem inflammatory syndrome in children, MIS-C）因其表现多样且可危及生命而备受重视。基于此背景，本研究聚焦印度东北部欠发达农村地区的MIS-C病例，由于经济限制，多数患者采用甲泼尼龙（methylprednisolone）而非静脉注射免疫球蛋白（intravenous immunoglobulin）进行治疗。 <em>方法</em> 本研究在甘地医学院（MGM Medical College）开展一项前瞻性纵向队列研究，纳入27例符合世界卫生组织（World Health Organization, WHO）诊断标准的MIS-C病例。根据诊断及预后评估需求，开展实验室及影像学检查，包括超声心动图（echocardiography）。多数患者接受甲泼尼龙治疗。于患者出院后6周进行随访评估，以排查是否存在残留功能损害。 <em>结果</em> 最常受影响的年龄组为5~10岁（59.28%），呼吸系统（48.14%）与心血管系统（40.74%）为最常受累的系统。Logistic回归分析显示，血清铁蛋白水平与住院时间延长存在显著关联（系数0.0674，p=0.0041），其原因可能为铁蛋白水平较高的患者并发症更多。器官功能损害与正性肌力药物使用需求增加显著相关（系数3.8797，p=0.00584）。多数病例（85.18%）仅接受甲泼尼龙单一治疗，疗效良好且无死亡病例发生。 <em><strong>结论</strong></em> 仅接受甲泼尼龙治疗的患者获得良好疗效，证实了该药物作为资源匮乏环境中廉价替代方案的有效性。本研究表明，复杂病例中较高的铁蛋白水平会导致住院时间延长，而存在器官功能损害的患者则更需要使用正性肌力药物。