VHL:ElonginC:ElonginB-PROTAC4 complex

VHL:ElonginC:ElonginB-PROTAC4 complex Descriptor: Elongin-B, Elongin-C, N-[5-(1-{2-[4-({[(1S,2R,3S,5S,6S,16E,18E,20R,21S)-11-chloro-21-hydroxy-12,20-dimethoxy-2,5,9,16-tetramethyl-8,23-dioxo-4,24-dioxa-9,22-diazatetracyclo[19.3.1.1~10,14~.0~3,5~]hexacosa-10(26),11,13,16,18-pentaen-6-yl]oxy}carbonyl)phenyl]ethyl}-1H-1,2,3-triazol-4-yl)pentanoyl]-3-methyl-D-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, ... Authors: Maiocchi, A, Abel, A.-C, Steinmetz, M.O, Passarella, D, Prota, A.E. Deposit date: 2024-10-15 Release date: 2025-10-29 Last modified: 2026-05-13 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Effective Tubulin Degradation by Rationally Designed Proteolysis Targeting Chimeras Biorxiv, 2025