Hydrogel-Forming Microneedle Arrays Allow Detection of Drugs and Glucose In Vivo: Potential for Use in Diagnosis and Therapeutic Drug Monitoring - Fig 6

(A) Quantity of glucose (μg) taken up in vitro by MN arrays 5 and 60 min after insertion into dermatomed excised neonatal porcine skin mounted on modified Franz cells and bathed on the underside by phosphate buffered saline pH 7.4 thermostated to 37°C and containing defined concentrations of of glucose (Means ± SD, n = 6). (B) Comparison of glucose (μg) detected in plasma versus levels detected from MN arrays inserted in the forearm of human volunteers at defined time points preceding (-1-0 h) and following (0–1, 1–2, 2–3 and 0–3 h) oral administration of 75 g of glucose (Means ± SD, n = 9).