CSF-FA in human obesity

Hypothalamic inflammation (HI) is a key factor in the onset of obesity. Magnetic resonance imaging (MRI) studies have demonstrated the presence of hypothalamic alterations that might indicate HI in subjects with obesity. However, the contribution of dietary factors, such as fatty acids, to these alterations has not been explored in humans.

We aimed to compare the cerebrospinal fluid fatty acid (CSF-FA) profile between individuals with obesity before and 1-year after bariatric surgery (BS) and normal-weight volunteers and, to assess the association between those CSF-FA differently expressed between groups with MRI markers of HI and the weight-loss trajectory post-BS.

Herein, we present the results obtained through ultra-high performance liquid chromatography–mass spectrometry (UHPLC-MS).