Performance of the various TNM staging systems, BCLC and Hangzhou criteria systems.

In the univariate model, the highest χ2 by the linear trend test, likelihood ratio (LHR) test, and highest c-index were considered to indicate best prognostic performance in terms of discriminatory ability, homogeneity, and monotonicity of gradients. In the multivariate Cox regression model,the independent contributions of each staging system to the full model were evaluated by removing the system concerned. AIC, Akaike information criterion; TNM, tumor-node- etastasis; BCLC, Barcelona Clinic Liver Cancer; HC, Hangzhou criteria.