ATAC-seq of wildtype or Dppa2 knockout ESC upon release of the epigenetic editing trigger. ATAC-seq of wildtype or Dppa2 knockout ESC upon release of the epigenetic editing trigger

Chromatin accessibility was assayed in wildtype or Dppa2 knockout ESC after 26 days of release of the trigger imposed by epigenetic editing. Samples were collected in two clonal knockout and wildtype lines after sorting at FACS of cells which maintained a repressive Esg1-tdTomato (TOMneg) reporter expression after 26 days of DOX washout (release of the trigger).