Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47
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Crystal Structure of human PARP-1 CAT domain bound to inhibitor EB-47 Descriptor: 2-[4-[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]carbonylpiperazin-1-yl]-N-(1-oxidanylidene-2,3-dihydroisoindol-4-yl)ethanamide, Poly [ADP-ribose] polymerase 1, SULFATE ION Authors: Steffen, J.D, Pascal, J.M. Deposit date: 2020-01-21 Release date: 2020-06-17 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structural basis for allosteric PARP-1 retention on DNA breaks. Science, 368, 2020
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2020-01-21
