Additional file 6 of Development and validation of a horse reference panel for genotype imputation

Additional file 6: Table S3. High-impact variants in the variants call set of 317 horses. High-impact variants identified by variant effect prediction were tested for a significant absence or reduction of homozygotes using a binomial test under the assumptions of Hardy-Weinberg equilibrium. The obtained p-values were adjusted for multiple testing using Bonferroni correction. Variants that affect more than one gene or have different effects on different isoforms of a protein are listed multiple times, once for each gene/isoform. However, for significance testing, each variant was only considered once.