Transcriptome profiling of TNFa-stimulated urothelial cells

In this study, we aimed to determine the overall effect of TNFa on transcriptomic profile of urothelial cells using RNA sequencing. Our study represents a reference database that could lead to a better understanding of the role of urothelial cells in IC/BPS pathology and more importantly, sets grounds for future studies exploring potential biomarkers and therapeutic targets for IC/PBS diagnosis and treatment. Overall design: Comparative gene expression profiling analysis of RNA-seq data for RT4 urothelial cancer cells (untreated vs TNFa-treated, three independent experiments).