Genes specifically deregulated in one of the two pathways of bladder cancer pathogenesis.

SAM analysis of the deregulated genes was performed comparing their expression, for a given stage, FGFR3-mutated tumors and FGFR3-non-mutated tumors. Only the genes found differentially expressed are presented. SYTL1, which is down-regulated in FGFR3-non-mutated T2–4 tumors compared to normal urothelium (first 2 columns and Table 2) is also specifically down-regulated in FGFR3-non-mutated T2–4 tumors compared to FGFR3-mutated T2–4 tumors (last 2 columns). LEPRE1, MICAL2, RAB23 and STXBP1, which are up-regulated in FGFR3-non-mutated T2–4 tumors compared to normal urothelium (first 2 columns and Table 2) are also specifically up-regulated in FGFR3-non-mutated T2–4 tumors compared to FGFR3-mutated T2–4 tumors (last 2 columns). FC: Fold Change.