Phosphatase inhibitor PPP1R11 modulates resistance of human T cells towards Treg-mediated suppression of TCR signaling
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE124757
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We have performed RNAseq analysis of human T cells upon PPP1R11 siRNA silencing. We have explored the role of PPP1R11 for the first time in primary human T cells and discovered that PPP1R11 is a novel negative mediator of T cell activation. CD4+ T cells from 3 donors were treated with either control or PPP1R11 siRNA for 4.5 days and either stimulated with cross linked CD3/CD28 for 6h or left unstimulated for RNAseq analysis
创建时间：
2019-06-07
