Comparison of the robustness/fragility of CA with other viral sequences*.

*Table describes single residue mutagenesis studies that were (i) random (i.e. the cohort of mutants was not selected, and did not have amino acid bias) (ii) analysed proteins or domains greater than 10 aa in length, and (iii) had datasets that included at least 5 mutants.#Fragility, when not stated clearly in the published work, was deduced using the % of mutants either indicated as ‘lethal’ or that had 2% or less fitness or function compared to WT, using the available analyses of fitness or function utilized in the study. In most cases, wording of summary/notes mimics the author's assessment as closely as possible.