In severe COVID-19, SARS-CoV-2 induces a chronic, TGF-ß-dominated adaptive immune response (Bronchoalveolar lavage)

Single cell transcriptome, TCR and BCR sequencing of FACS-sorted CD45+ cells of the bronchoalveolar lavages of COVID-19 ICU patients Overall design: Sequencing of RNA, TCR and BCR was performed from FACS-sorted CD45-positive cells from the bronchoalveolar lavage of 2 COVID-19 ICU patients (one at 2 different time points), using the 10X Genomics platform with the Single Cell 5' Library & Gel Bead Kit