Monocyte signature as a predictor of chronic lung disease in the preterm infant

The early changes in innate immunity associated with BPD (bronchopulmonary dysplasia) development are incompletely understood. Transcriptome analyses from cord blood of preterm infants indicate a monocyte-centered, profibrotic signature at birth confirming TNFalpha as a critical upstream regulator for the development of BPD. Differential expression analyses of perterm infants with no BPD versus mild or moderate/severe BPD