Transcriptome-wide RNA and genome-wide DNA G-Quadruplex mediates alternative transcripts

We demonstrate that G4-DNA and G4-RNA may present splicing sites and alternative transcription starting positions on a transcriptome-wide and genome-wide scale by showing widespread effect on alternative transcripts in response to the established intracellular G4 binding ligands PDS. Overall design: Examination of transcripts following PDS treatment in HCT116 and rat NP cells.