Biopharmaceutical proteins are produced in mammalian cells by transient expression or stable transformation, but both processes require robust and viable cells. Cell line engineering must therefore ba
Comprehensive identification of activated biological processes and pathways in Chinese hamster ovary (CHO) cells and Chinese hamster lung (CHL)-YN cells by transcriptome profiling, with a focus on the
Actinoplanes sp. SE50/110 is known as the wild type producer of the ?-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. Derived strains with in
Chinese Hamster Ovary (CHO) cell lines are preferred host cells for therapeutic protein production. line. The availability of the CHO genome ushers in an era of genome-scale science and metabolic engi
