Cholesterol metabolism with Bloch and Kandutsch-Russell pathways

This pathway is inspired by the Lipidmaps>Sterol lipids expended pathway display [https://lipidmaps.org/pathway/pathways_maps] and extended with Scheme 1 from Acimovic et al (2013 [https://www.ncbi.nlm.nih.gov/pubmed/23558541]). Literature suggests that cholesterol synthesis preferentially starts with the Bloch pathway, however there is a shift to the Kandutsch-Russell part via lathosterol (Bae et al, 1997[https://www.ncbi.nlm.nih.gov/pubmed/9291139]). Dashed lines indicate that multiple steps are involved to create the final product. Several regulatory effects concerning the metabolites of cholesterol have been indicated as well. The content from the Bloch and Kandutsch-Russel pathways have been checked against literature, and differences compared to the original LipidMaps pathway have been coloured turquoise.

本途径借鉴于 Lipidmaps>Sterol 脂质途径展示 [https://lipidmaps.org/pathway/pathways_maps]，并扩展了 Acimovic 等人于 2013 年提出的方案 1 [https://www.ncbi.nlm.nih.gov/pubmed/23558541]。文献指出，胆固醇合成的优先途径为 Bloch 途径，然而，通过麦角甾醇（Bae 等人，1997[https://www.ncbi.nlm.nih.gov/pubmed/9291139]）的转化，存在向 Kandutsch-Russell 部分的转变。虚线表示涉及多个步骤以形成最终产物。同时，胆固醇代谢物的若干调控效应亦已标明。Bloch 和 Kandutsch-Russel 途径的内容已对照文献进行核对，与原始 LipidMaps 途径的差异已以湖蓝色调标注。

搜集汇总

背景与挑战

背景概述

该数据集详细描述了小鼠胆固醇代谢的Bloch和Kandutsch-Russell途径，包含多种代谢物和基因产物的信息，并引用了相关研究文献。