Short-term treatment of Diabetic NOD mice with anti-TNF-α therapy restores immune tolerance to beta cells.
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NOD-sp spontaneous new onset diabetic NOD mice; *NOD-sp/stz, a streptozotocin induced diabetic state was induced in NOD recipients. Spontaneously diabetic NOD mice (Groups C, D) were previously restored to a euglycemic state by anti-TNF-α treatment. These mice remained euglycemic 240–300 days following the cessation of treatment. Syngeneic NOD.SCID islet (Groups A, C) or allogeneic C57BL/6 (Groups B, D) islet grafts were transplanted into NOD recipients.
创建时间：
2012-05-11
