Effect of antibodies to TIM-3 and PD-Ligands on T cell responses to HIV-peptides.
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Specific responses to HIV-peptides: Gag/Nef peptide treated samples that had at least 2-fold higher responses than mock treated samples from the same donor; Enhanced responses: HIV-peptide responses in samples treated with TIM-3/PD-L antibodies were at least 1.5-fold higher than both controls (Gag/Nef peptide samples without antibody or treated with isotype control antibody). Response versus controls: The mean response in presence of TIM-3/PD-L antibodies was divided by the mean response of the controls. *in two samples the IFN-γ production in presence of TIM-3 antibodies was also more than 1.5-fold lower than in both controls; **in two samples the number of CFSElow cells in presence of TIM-3 antibodies was also more than 1.5 fold lower than in both controls. n.d.: not determined.
