Divergent C. elegans toxin alleles are suppressed by distinct mechanisms

Toxin-antidote elements (TAs) are selfish DNA sequences that bias their transmission to the next generation. TAs typically consist of two linked genes: a toxin and an antidote. The toxin kills progeny that do not inherit the TA, while the antidote counteracts the toxin in progeny that inherit the TA. We previously discovered two TAs in C. elegans that follow the canonical TA model of two linked genes: peel-1/zeel-1 and sup-35/pha-1 . Here, we report a new TA that exists in three distinct states across the C. elegans population. The canonical TA, which is found in isolates from the Hawaiian islands, consists of two genes that encode a maternally deposited toxin (MLL-1) and a zygotically expressed antidote (SMLL-1). The toxin induces larval lethality in embryos that do not inherit the antidote gene. A second version of the TA has lost the toxin gene but retains a partially functional antidote. Most C. elegans isolates, including the standard laboratory strain N2, carry a highly divergent ..., , , # supplementary data sets

[https://doi.org/10.5061/dryad.3ffbg79tq](https://doi.org/10.5061/dryad.3ffbg79tq)

## Description of the data and file structure

Supplementary materials for the manuscript: ** **Divergent *C. elegans *toxin alleles are suppressed by distinct mechanisms

##### Supplementary tables that are used to make the conclusions in the manuscript : Divergent *C. elegans* toxin alleles are suppressed by distinct mechanisms

1. Table S1: Strains - A table of strains that were used in or constructed for this paper. has the following columns:
1. Strain - strain name
2. Allele name - Kruglyak lab allele name
3. Genotype - relevant genotype information associated with the strain
4. Description - a description of what the strain is an what was used for
2. Table S2: Plasmids - A table of plasmids that were used in or constructed for this paper. has the following columns:
1. Strain - plasmid name
2. Genotype - genetic parts that comprise the plasmid
3. Descr...