An Unprecedented Approach to 4,5-Disubstituted Pyrimidine Derivatives by a ZnCl<sub>2</sub>-Catalyzed Three-Component Coupling Reaction
收藏NIAID Data Ecosystem2026-03-06 收录
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We have developed a ZnCl2-catalyzed three-component coupling reaction involving a variety of functionalized enamines, triethyl orthoformate, and ammonium acetate, which leads to the production of 4,5-disubstituted pyrimidine derivatives in a single step. The procedure can be successfully applied to the efficient synthesis of mono- and disubstituted pyrimidine derivatives, using methyl ketone derivatives instead of enamines.
创建时间：
2016-02-26
