A Formal Approach to Xylosmin and Flacourtosides E and F: Chemoenzymatic Total Synthesis of the Hydroxylated Cyclohexenone Carboxylic Acid Moiety of Xylosmin
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https://figshare.com/articles/dataset/A_Formal_Approach_to_Xylosmin_and_Flacourtosides_E_and_F_Chemoenzymatic_Total_Synthesis_of_the_Hydroxylated_Cyclohexenone_Carboxylic_Acid_Moiety_of_Xylosmin/4643497
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资源简介：
The
hydroxylated cyclohexenone carboxylic acid moiety of xylosmin
was synthesized in eight steps from benzoic acid. The key steps in
the synthesis involved the enzymatic dihydroxylation of benzoic acid
by the whole cell fermentation with Ralstonia eutrophus B9, and Henbest epoxidation. Early attempts led to the synthesis
of a C6 epimer of the methyl ester of the hydroxylated cyclohexenone
carboxylic acid moiety. The absolute stereochemistry of an advanced
intermediate was confirmed by X-ray crystallography. Complete characterization
of the previously reported but not fully characterized hydroxylated
cyclohexenone carboxylic acid is provided.
创建时间：
2017-02-10
