Overcoming trade-off between activity and specificity of CRISPR-Cas9
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资源简介：
Evaluation of new version of Sniper-Cas9, Sniper2.0
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创建时间：
2023-01-06
相关数据集
Additional file 3: of AlleleAnalyzer: a tool for personalized and allele-specific sgRNA design
Table S3. Comparison of AlleleAnalyzer features with other commonly used CRISPR sgRNA design tools. (XLSX 12 kb)
NIAID Data Ecosystem90
Additional file 1 of Evaluation of CRISPR gene-editing tools in zebrafish
Additional file 1: Supplementary Figure 1. Editing efficiencies across 50 gRNAs with different GC content. Supplementary Figure 2. Mosaicism predicted using Illumina sequencing of G0 mutant larvae. Su
Figshare2022-01-06 更新60
Number of sgRNAs present in each data set before and after filtering with GuideScan.
(XLSX)
NIAID Data Ecosystem50
Directed evolution of CRISPR-Cas9 to increase its specificity
We have developed novel E.coli based directed evolution screening methodology, which elegantly eliminates both the mutants with weak on-target activities and the mutants with high off-target activitie
NIAID Data Ecosystem90
ChIP-seq analysis of dCas9 chromatin occupancy in HeLa cells expressing LAMPS. ChIP-seq analysis of dCas9 chromatin occupancy in HeLa cells expressing LAMPS
Significant enrichment of dCas9 chromatin occupancy at the targeted HS2 enhancer was observed in cells expressing LAMPS under the dark condition and after blue light illumination. Overall design: ChIP
NIAID Data Ecosystem50
