In vitro selection of viruses resistant to MAb neutralization.
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aIn vitro selection for neutralization escape variants was performed by passaging CHIKV-LR in the presence of 25 µg/ml of the indicated MAbs. Resistant virus was isolated at passage 3 (CHK-102, CHK-152, and CHK-263) or passage 6 (CHK-166), plaque purified, and sequenced.bThe A89E mutant was identified after sequencing of CHK-152 escape mutants in cell culture, but was determined to be insignificant for CHK-152 neutralization by reverse genetic analysis (see Fig. 6F).
创建时间：
2015-12-02
