Overview of compounds used for training and evaluation of classifiers.

The table lists all compounds along with their carcinogenicity class and CAS Registry Number. Corn oil (CO) or 0.1% carboxymethyl cellulose (CMC) was used as vehicle. Doses were selected for each compound based on the tumorigenic dose rate 50 (TD50), long-term animal studies leading to liver cancer known from the literature or initial dose range-finding studies. After a dosing period of 3 or 14 days the mouse livers were subjected to gene expression analysis using an Affymetrix platform. Two treatment groups, each comprising 5–6 male and female mice, respectively, were examined for each compound, dose and point of time. Time matched control groups were included for both vehicles. Each treatment group has a unique group ID which is composed of the compound short name, the group number and the sex (Female or Male).