Gut microbiome-derived LPS aggravated cognitive impairment by promoting systemic inflammation via the TLR4/MyD88/NF-κB signaling pathway in hypoxic-ischemic neonatal rats

Hypoxic ischemic brain damage (HIBD) is the primary cause of neurological deficits in neonates, leading to long-term cognitive impairment. Recent studies have demonstrated that gut microbiota plays a crucial role in the development of cognitive impairment after brain injury, known as the microbiota-gut-brain axis. RNA sequencing analysis of colon and hippocampus tissues was also conducted.