Access to SCF3 substituted indolizines via a photocatalytic late-stage functionalization protocol

A mild, scalable, and highly chemoselective photocatalytic method was developed for the direct indolizine functionalization with N-((trifluoromethyl)thio)saccharin, yielding high amounts of desired products while tolerating various functional groups. The photoredox catalyst employed offers a straightforward and inexpensive alternative to commercially available catalysts. Additionally, a 3-SCF₃ analogue of a histamine H3 receptor antagonist was synthesized with excellent yield, demonstrating the strategy’s potential in developing biologically relevant molecules., , All NMR-Data FID files were recorded by either a BRUKER Digital AVANCE 400 MHz FT-NMR or a BRUKER Digital AVANCE III 600 MHz FT-NMR., # Data from: Access to SCF3-substituted indolizines via a photocatalytic late-stage functionalization protocol

https://doi.org/10.5061/dryad.v6wwpzh7x

FID_for_Publication.zip

The dataset contains the zip File “FID\_ for Publication.zip” and contains the primary NMR data files (FID files, acquisition data, processing parameters) for the article: “Access to SCF3Substituted Indolizines via a Photocatalytic Late-Stage Functionalization Protocol” published in Organic Letters [https://pubs.acs.org/doi/10.1021/acs.orglett.5c02079](https://pubs.acs.org/doi/10.1021/acs.orglett.5c02079). The article is published open access. The zip file was submitted to the ACS Chemistry Databank and has been structured according to the Journal's regulations.

The first level of subfolders is named using the compound numbers from the article. In each of the folders, a structure file in Molfile is provided. Each spectrum folder of each compound was named according to the type of nucleus measured: [1H] Proton n...