Drug-level analyses.

Covariate-adjusted hazards of changes in drug discontinuation, switching, and covariate-adjusted odds of reduced drug adherence after reaching the coverage gap spending threshold among propensity score matched beneficiaries. Adjusted for the number of physician visits and hospitalizations, drugs used, drug spending, and Charlson comorbidity score in the postbaseline, predoughnut hole period after propensity score matching for baseline characteristics, which included: age, gender, race, region of the US, rural/urban residence, median household income, Charlson comorbidity score, number of office-based drug infusions, physician visits and hospitalizations, Medicare Parts A and B spending, and diagnosis of cancer, RA, cardiovascular conditions (atrial or ventricular fibrillation, hypertension, hyperlipidemia, hypercholesterolemia, myocardial infarction, angina, atherosclerosis, or congestive heart failure), depression, dementia, and/or diabetes.an Drugs available at cohort entry.bReduced adherence is defined as PDC