Testosterone delays bone loss and microstructural destruction in elderly men via osteoblast-androgen receptor-mediated upregulation of the fibrinogen C-terminus of tenascin-C

Bone loss in elderly males is associated with a high mortality rate because of fracture. A growing body of evidence indicates that low androgen levels are linked with bone loss in elderly men, suggesting that the regulatory role of androgen in aged male bones deserves more attention, and it is not enough to directly extrapolate to males what is known for females. In this project, we used proteomics to figure out the differentially expressed proteins induced by Tes during the metaphase stage and mature stage of osteoblast differentiation. In addition, TNC peptide inhibited the osteoclasts formation. To explore the mechanism, proteomics was also performed using TNC peptide-stimulated osteoclasts cell lysates.