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Dataset for article: Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition

NIAID Data Ecosystem2026-05-02 收录

NMDA受体调节

神经肽药物设计

数据链接：

https://zenodo.org/record/12804752 数据链接链接失效反馈

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This version shows the correct number of n for Figure 6.

应用场景：

创建时间：

2024-08-28

NMDA受体

神经肽药物设计

Structure of the human GluN1/GluN2A LBD in complex with GNE0723 Descriptor: (1~{R},2~{R})-2-[7-[[5-chloranyl-3-(trifluoromethyl)pyrazol-1-yl]methyl]-5-oxidanylidene-2-(trifluoromethyl)-[1,3]thiazolo[3

Protein Data Bank Japan2024-11-06 更新70

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

海马突触可塑性

NMDA受体调节

Ubiquitin-specific protease (USP) 6 is a hominoid deubiquitinating enzyme previously implicated in intellectual disability and autism spectrum disorder. Although these findings link USP6 to higher bra

Figshare2019-12-16 更新40

Benzyl Phenylsemicarbazides: A Chemistry-Driven Approach Leading to G Protein-Biased Dopamine D4 Receptor Agonists with High Subtype Selectivity

偏向性受体激动剂

神经肽药物设计

Many subtype-selective dopamine receptor ligands developed for the D2–D4 family incorporate a 1-arylpiperazine-derived primary recognition motif, which is connected to a lipophilic moiety occupying an

Figshare2019-10-15 更新10

MBD5 regulates NMDA receptor expression and seizures by inhibiting Stat1 transcription [RNA-Seq]

癫痫分子机制

NMDA受体调节

Epilepsy is considered to result from an imbalance between excitation and inhibition of the central nervous system. Pathogenic mutations in the methyl-CpG binding domain protein 5 gene (MBD5) are know

NIAID Data Ecosystem60

Reduced Mg2+ block of N-methyl-D-aspartate receptor-mediated synaptic potentials in developing visual cortex.

视觉皮层发育可塑性

NMDA受体调节

Molecular cloning has demonstrated a diversity of artificially expressed N-methyl-D-aspartate (NMDA) receptors, implying a similar diversity of naturally occurring NMDA receptors in situ. Particularly

PubMed Central1993-08-01 更新30

Dataset for article: Potent and reversible open-channel blocker of NMDA receptor derived from dizocilpine with enhanced membrane-to-channel inhibition

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