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Total Synthesis of Septocylindrin B and C-Terminus Modified Analogues

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https://figshare.com/articles/dataset/Total_Synthesis_of_Septocylindrin_B_and_C_Terminus_Modified_Analogues__/115687
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资源简介:
The total synthesis is reported of the peptaibol Septocylindrin B which is related to the well documented channel forming peptaibol antibiotic Alamethicin. Several analogues were synthesized with a modified C-terminus, to investigate the SAR of the terminal residue Phaol. All these peptides were tested for their membrane perturbation properties by fluorescent dye leakage assay and for their antibacterial activity.
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2012-12-20
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