Transcriptomic exploration of decidualizing human endometrial stromal cell dynamics

Spontaneous decidualization of the endometrium in response to progesterone signaling is confined to menstruating species, including humans and other higher primates. During this process, endometrial stromal cells (EnSCs) differentiate into specialized decidual cells that control embryo implantation. We subjected undifferentiated and decidualizing human EnSCs to RNA-sequencing (RNA-seq) to measure global changes in transcription. Overall design: We subjected decidualising primary human endometrial stromal cells to RNA sequencing (RNA-seq) to map the underlying gene expression changes.