Human Uterosacral Ligament Analysis: Raw POP-HQ histological data and steroid receptor immunohistochemical staining data

Reference for the POP-HQ system for histological analysis (Excel file first sheet): Orlicky DJ, Guess MK, Bales ES, Rascoff LG, Arruda JS, Hutchinson-Colas JA, Johnson J, Connell KA. Using the novel pelvic organ prolapse histologic quantification system to identify phenotypes in uterosacral ligaments in women with pelvic organ prolapse. Am J Obstet Gynecol. 2021 Jan;224(1):67.e1-67.e18. doi: 10.1016/j.ajog.2020.10.040. Epub 2020 Oct 30. PMID: 33130030 Legend for Sheet 1: POP-HQ Scoring of Study Tissues. POP-HQ histopathological scoring data plus the 4 main demographic features for the patient samples used in the study. All histopathologic scoring for the USLs used in this study are included, as well as the main demographic data, age, smoking status, (0=non-smoker, 1=smoker), parity, and body mass index (BMI), and menopause status plus hormone replacement used in the three previous months. Boxes are included to show that the POP-A phenotype does contain adipose (Adipo), the POP-I phenotype does contain lots of neutrophil inflammation (Inflam), and the POP-V phenotype does contain lots of NIH (TI thick). See (ref below) for details of the scoring. Legend for Sheet 2: Receptor Staining Scores. All ERα, ERβ, GPER, and AR IHC data for all subjects is shown. All receptor scoring data for the USLs used in this study are included. Abbreviations in the table include: ERα -SM, estrogen receptor alpha smooth muscle fascicle myocytes; ERα -CT, estrogen receptor alpha connective tissue cells; ERβ-SM, estrogen receptor beta smooth muscle fascicle myocytes; ERβ-ASM, estrogen receptor beta tunica media smooth muscle myocytes; ERβ-CT, estrogen receptor beta connective tissue cells; GPER-SM, G-protein estrogen receptor smooth muscle fascicle myocytes; GPER-ASM, G-protein estrogen receptor tunica media smooth muscle myocytes; GPER-EC, G-protein estrogen receptor endothelial cells; GPER-CT, G-protein estrogen receptor connective tissue cells; AR-SM, androgen receptor smooth muscle fascicle myocytes; AR-CT, androgen receptor connective tissue cells.