mRNA技术在传染病和病毒诱发癌症疫苗研发中的潜在优势和局限性
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ThereportrecommendsaframeworktoassessthevalueofmRNAtechnologyindevelopingvaccinesandtherapeuticsagainstotherinfectiousdiseases.Aframeworkcouldalsohelpestablishthetechnology’spotentialroleinaddressingcancerandautoimmunediseases.Toinformsuchaframework,thereportmapsouttheclinicaltrialstatusofmRNAvaccinesinthemostadvancedstagesofdevelopment.WhiletheCOVID-19vaccinesaretheonlysafeandefficaciouspreventivemRNAvaccinesdevelopedandapprovedforhumanusetodate,mRNAvaccinesagainstcytomegalovirus(acommonvirusthatcanthreatenbabiesandthosewithaweakenedimmunesystem),influenzaAandB,andRSVareinPhase3trials.Thereisalsoon-goingdiscoveryworkintuberculosis,malaria,HIVaswellasnoncommunicablediseases.Thereportalsocallsforfurtherresearchtoaddressthepotentialofthistechnologyaswellasitslimitations.ImprovingthestabilityofmRNAvaccinesathighertemperaturesshouldbeakeytargetofinvestmentandresearchefforts.Anotherkeyrecommendationisensuringend-to-enddevelopmentandaccessbywayofinvestmentandapplyinglessonsfromCOVID-19initiatives,suchastheACT-Accelerator,whichworkedtosecureaccesstoCOVID-19tests,treatments,andvaccines.
