首页/数据集/The DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination

The DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination

ChEBI2013-10-22 更新2026-07-21 收录

免疫球蛋白类别转换重组

DSIF复合物调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-33206 数据链接链接失效反馈

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The DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination

应用场景：

创建时间：

2013-10-22

免疫球蛋白类别转换重组

DNA双链断裂修复途径选择

Immunoglobulin class switch recombination (CSR) plays an important role in humoral imm\une responses by changing the effector functions of antibodies. CSR occurs between highly repetitive switch (S) s

NIAID Data Ecosystem80

Molecular characterization of hybridoma subclones spontaneously switching at high frequencies in vitro

免疫球蛋白类别转换重组

杂交瘤细胞基因表达

This is a comparative microarray analysis of 36-65 hybridomas switching at normal low frequencies in vitro vs. selected variants spontaneously switching at 100 fold higher frequencies in vitro. This

NIAID Data Ecosystem50

53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ

DNA双链断裂修复

免疫球蛋白类别转换重组

53BP1 governs a specialized, context-specific branch of the classical non-homologous end joining DNA double-strand break repair pathway. Mice lacking 53bp1 (also known as Trp53bp1) are immunodeficient

NIAID Data Ecosystem40

Transgenes of the Mouse Immunoglobulin Heavy Chain Locus, Lacking Distal Elements in the 3′ Regulatory Region, Are Impaired for Class Switch Recombination

免疫球蛋白类别转换重组

细胞基因调控

The immunoglobulin heavy (H) chain class switch is mediated by a deletional recombination event between µ and γ, α, or ε constant region genes. This recombination event is upregulated during immune re

NIAID Data Ecosystem50

YY1 Controls Em-3’RR DNA Loop Formation and Immunoglobulin Heavy Chain Class Switch Recombination.

免疫球蛋白类别转换重组

DNA环形成机制

Activation of splenic B cells induces formation of a 220kb DNA loop between Em and 3’RR enhancers in the immunoglobulin heavy chain locus (IgH). This DNA loop has been proposed to be necessary for th

NIAID Data Ecosystem40

The DSIF subunits Spt4 and Spt5 have several unexpected, distinct roles in regulating immunoglobulin class switch recombination

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