: Selection of Ngn3-activated genes in suspension cultured human duct cells.

140 transcripts on HG133A array transcripts are at least 1.5-fold (LB) activated by AdGFP-Ngn3 in human duct cells. Ngn3-activated genes are statistically enriched (P<0.001) in gene ontologies of development, neurogenesis, synaptic transmission, regulated hormone secretion and nuclear regulators; genes belonging to these clusters are shown. From left to right, columns indicate fold transcript accumulation in AdGFP-Ngn3 versus AdGFP control cells at 3 (D3) or 14 (D14) days post transduction. Two columns on the right refer to the analysis of tissue tropism in Figure 1: endocrine cell abundance indicates relative mRNA abundance in human endocrine cells as compared to the other tissues profiled in Figure 1. Last column indicates in which cluster (A, B, C) of Figure 1 the gene is situated.
*P<0.05, n = 3.