CenhANCER

Here, we developed CenhANCER, a comprehensive cancer enhancer database, based on H3K27ac ChIP-Seq datasets of 805 primary cancer tissues and 671 cancer cell lines across 49 cancer types. In total, we identified 29,815,953 typical enhancers and 516,447 super enhancers (SE) for the primary tissues, and 27,213,455 typical enhancers, 461,964 super enhancers for the cell lines. To strengthen the regulatory roles of the super-enhancers, we further integrated expression quantitative trait locus (eQTLs) , and risk SNPs into CenhANCER. We also identified transcription factors, whose binding sites were enriched for enhancers in each sample, which are potential therapeutic targets.

搜集汇总

背景与挑战

背景概述

CenhANCER是一个综合性癌症增强子数据库，基于805个原发癌组织和671个癌细胞系的H3K27ac ChIP-Seq数据，覆盖49种癌症类型。它识别了数千万个典型增强子和数十万个超级增强子，并整合了eQTLs、风险SNPs以及转录因子信息，以强化调控作用并探索潜在治疗靶点。