Initial conditions and parameters that vary by study.

a Calculated from information in [8] on surface densities and VEGF concentration, and used to calculate [M]. b Tuned so total surface Vs·R2 + internal VEGF matches data in [8]. c The original kint value was used for [V] < 50 ng/mL (trafficking study [40], 2011 presentation study [8], Anderson et al. 2011 Validation study [59], Mellberg et al. [60]), as well as for all model predictions. kint/6 was used for [V] > 50 ng/mL (2010 presentation study [29], Martino et al. Validation study [61], and Mattila et al. [62]). In cases where [V] = 50 ng/mL, the value that resulted in better fits was used. d References: [12, 63] Initial conditions and parameters that vary by study.