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Dual targeting of mitochondrial Complex I and Metal Ion Homeostasis by WX006 induces Metabolic Collapse in HCC

NIAID Data Ecosystem2026-05-02 收录

细胞癌靶向治疗

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数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP582741 数据链接链接失效反馈

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资源简介：

This sequencing data records the pharmacological regulatory effect of the novel anti-tumor small molecule compound WX006 on the hepatoma cell line Hep3B

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创建时间：

2025-06-01

核糖体生物学

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The ribosome has considerably increased in size during metazoan evolution in the form of an RNA shell that could serve as a platform for yet unknown protein interactions. Here, we have comprehensively

干细胞与再生医学数据中心2022-02-20 更新110

DataSheet1_Transcriptome Profiling of Osteoblasts in a Medaka (Oryzias latipes) Osteoporosis Model Identifies Mmp13b as Crucial for Osteoclast Activation.docx

骨质疏松分子机制

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Matrix metalloproteases (MMPs) play crucial roles in extracellular matrix (ECM) modulation during osteoclast-driven bone remodeling. In the present study, we used transcriptome profiling of bone cells

NIAID Data Ecosystem40

Study of Aifm2, a NADH oxidase, supports robust glycolysis and is required for cold- and diet-induced thermogenesis. Nguyen et al.

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产热机制

Aifm2, a NADH oxidase, supports robust glycolysis and is required for cold- and diet-induced thermogenesis

NIAID Data Ecosystem40

The transcriptomic changes induced by NREP downregulation in HepG2 cells

细胞转录组

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To evaluate the global transcriptomic changes induced by Neuronal Regeneration Related Protein (NREP) downregulation, we employed RNA-sequencing in HepG2 cells lacking NREP. Enriched pathway analyses

NIAID Data Ecosystem100

Transcriptomic analyses of ChREBPtotal-null mice and ChREBPβ-null mice liver. Transcriptomic analyses of ChREBPtotal-null mice and ChREBPβ-null mice liver

转录组学

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The Carbohydrate Responive Element Binding Protein (ChREBP) is a transcription factor sensing glucose. Two isoforms are produced by the same gene, the long isoform ChREBPalpha and the short one ChREBP

NIAID Data Ecosystem40

Dual targeting of mitochondrial Complex I and Metal Ion Homeostasis by WX006 induces Metabolic Collapse in HCC

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