Median value of blood parameters over time according to severity of gastrointestinal symptoms after ingestion of whipworm T. suis eggs (N = 49) in a randomized double-blind clinical trial of T. suis for grass-pollen allergy, Denmark, 2008.

*PT. suis-specific antibodies per liter serum; kUA/l, kilo units antibodies per liter serum.†P-value for a test for homogeneity between trends over time (in mean values) in each severity group. Intersubject correlation was taken into account.‡Each subject had one blood sample drawn during the grass pollen season (May 28 to July 27), and all sampling days were then categorized into 1st period (visit 3 of 9, n = 8; visit 4 of 9, n = 10) and 2nd period (visit 5 of 9, n = 27; visit 6 of 9, n = 6) to obtain meaningful results by severity subgroups. The mean day of 1st period was day 59 (range 43–69), 2nd period day 90 (range 81–117), and end day 170 (162–185).††Calculated for each subjects as total IgE minus the total sum of IgE against T. suis, grass- and birch-allergen.‡‡The result of planned analyses (data not shown) executed on the date (March 4, 2009) the study was unblinded.The placebo group is not shown.