Accumulation ratios for darapladib and SB-553253 for multiple relative to single dosing of darapladib.

Ro = Observed accumulation ratio; Rp = Predicted accumulation ratio; Rs = Steady-state accumulation ratio; RCmax = Cmax accumulation ratio; AUC(0-τ) = Area under the concentration-time curve over the dosing interval; AUC(0-∞) = Area under the concentration-time curve from time zero (pre-dose) extrapolated to infinite time; CVw%: within-subject coefficient of variation; GLS mean = Geometric least square mean; NA: Not applicable Accumulation ratios for darapladib and SB-553253 for multiple relative to single dosing of darapladib.