Gene expression profiles in rat lung following intratracheal instillation with cellulose nanofibrils and multi-walled carbon nanotubes

To evaluate the biological effects at the transcriptional level of manufactured nanomaterials, whole genome microarray analysis of rat lungs intratracheally instilled with cellulose nanofibrils (CNFs) with different physicochemical properties or multi-walled carbon nanotubes (MWCNTs) were performed. Rats intratracheally instilled with three types of CNFs (CNF1, CNF2, and CNF3), MWCNTs (0.5, 1.0 and 2.0 mg/kg), and their solvents as vehicle control were dissected at 1day, 3 days, 7 days, 30 days, and 90 days post-instillation, and then the lungs were used for microarray analysis.